Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 1.00 |
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | PRKACG | P22612 | 2/20 | 0.50 |
| ▸ | PRKACB | P22694 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12675368 | 0.77 | SRC (0.63) | SRCHTR6CXCL8NOD1PSEN1 | |
| SCHEMBL12093313 | 0.75 | HTR6 (0.70) | SRCHTR6CXCL8NOD1PSEN1 | |
| SCHEMBL7980685 | 0.75 | SRC (0.59) | SRCHTR6NOD1 | |
| SCHEMBL1898801 | 0.74 | HTR6 (0.58) | SRCHTR6CXCL8NOD1 | |
| SCHEMBL13387230 | 0.74 | SRC (0.58) | SRCHTR6CXCL8NOD1PSEN1 | |
| SCHEMBL5377982 | 0.73 | SRC (0.58) | SRCHTR6CXCL8NOD1PSEN1 | |
| SCHEMBL12344903 | 0.72 | SRC (0.56) | SRCHTR6CA12CA2CA9 | |
| SCHEMBL10141904 | 0.72 | SRC (0.56) | SRCHTR6PSEN1PSEN2APH1B | |
| SCHEMBL13387051 | 0.72 | SRC (0.56) | SRCHTR6PSEN1PSEN2APH1B | |
| SCHEMBL8610386 | 0.71 | SRC (0.55) | SRCHTR6PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |