Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988491 | 0.85 | ADORA2A (0.38) | ADORA2ALMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7985000 | 0.83 | ADORA2A (0.40) | ADORA2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7975267 | 0.81 | SMN1; SMN2 (0.46) | ADORA2ALMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7988251 | 0.81 | NR1H3 (0.43) | ADORA2APOLBALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL7985379 | 0.80 | TLR8 (0.44) | ALDH1A1SMN1; SMN2NPSR1HPGD | |
| SCHEMBL7974615 | 0.79 | ADORA2A (0.44) | ADORA2AALDH1A1ADORA3ADORA1 | |
| SCHEMBL7974065 | 0.79 | TLR8 (0.43) | ADORA2AALDH1A1SMN1; SMN2NPSR1HPGD | |
| SCHEMBL7984717 | 0.79 | SMN1; SMN2 (0.46) | ADORA2ALMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7984788 | 0.79 | CYP11B1 (0.45) | PDE4DLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7984242 | 0.77 | CNOT7 (0.45) | ADORA2ALMNAPOLBALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |