Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988251 | 0.92 | NR1H3 (0.43) | ADORA2ANR1H3ADORA1ADORA3ACP1 | |
| SCHEMBL7985379 | 0.91 | TLR8 (0.44) | NR1H3CNR2 | |
| SCHEMBL7974065 | 0.90 | TLR8 (0.43) | ADORA2ANR1H3ADORA3CNR2 | |
| SCHEMBL7988491 | 0.89 | ADORA2A (0.38) | ADORA2AADORA1ADORA3ACP1L3MBTL1 | |
| SCHEMBL7974615 | 0.85 | ADORA2A (0.44) | ADORA2AADORA1ADORA3 | |
| SCHEMBL7984242 | 0.83 | CNOT7 (0.45) | ADORA2AADORA1ADORA3 | |
| SCHEMBL7984498 | 0.83 | TLR7 (0.44) | ADORA2AADORA1ADORA3PDE4APDE4B | |
| SCHEMBL7975267 | 0.82 | SMN1; SMN2 (0.46) | ADORA2ANR1H3ADORA1ADORA3KMT2A | |
| SCHEMBL7984788 | 0.80 | CYP11B1 (0.45) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL7984717 | 0.80 | SMN1; SMN2 (0.46) | ADORA2AADORA1ADORA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |