Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985379 | 0.99 | TLR8 (0.44) | TLR8NPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL7988251 | 0.95 | NR1H3 (0.43) | TLR8NPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL7985000 | 0.90 | ADORA2A (0.40) | NR1H3CNR2ADORA3ADORA2A | |
| SCHEMBL7988491 | 0.84 | ADORA2A (0.38) | NPC1ALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7984242 | 0.84 | CNOT7 (0.45) | ALDH1A1KDM4ECNOT7HTTADORA3 | |
| SCHEMBL7974615 | 0.81 | ADORA2A (0.44) | ALDH1A1CNOT7HTTADORA3ADORA2A | |
| SCHEMBL7984498 | 0.79 | TLR7 (0.44) | ALDH1A1HPGDSMN1; SMN2NPSR1ADORA3 | |
| SCHEMBL7975267 | 0.78 | SMN1; SMN2 (0.46) | ALDH1A1HPGDSMN1; SMN2CNOT7NR1H3 | |
| SCHEMBL7985784 | 0.78 | LMNA (0.40) | ALDH1A1HPGDADORA2A | |
| SCHEMBL7985284 | 0.78 | TLR4 (0.35) | TLR8NPC1ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |