Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984532 | 0.89 | RAB9A (0.49) | KDRPAK4LRRK2PDPK1KMT2A | |
| SCHEMBL7982075 | 0.89 | PAK4 (0.43) | KDRGSK3BPAK4LRRK2NPC1 | |
| SCHEMBL6980872 | 0.89 | PAK4 (0.43) | KDRGSK3BPAK4LRRK2NPC1 | |
| SCHEMBL7985455 | 0.88 | JAK3 (0.44) | KDRPAK4LRRK2PDPK1JAK3 | |
| SCHEMBL6982836 | 0.88 | JAK3 (0.44) | KDRPAK4LRRK2PDPK1JAK3 | |
| SCHEMBL8192969 | 0.87 | HTT (0.45) | KDRPAK4LRRK2JAK3KMT2A | |
| SCHEMBL4493857 | 0.86 | PLK1 (0.46) | KDRKMT2AMEN1 | |
| SCHEMBL4493853 | 0.86 | PLK1 (0.46) | KDRKMT2AMEN1 | |
| SCHEMBL7088642 | 0.86 | PDPK1 (0.44) | KDRGSK3BLRRK2PDPK1KMT2A | |
| SCHEMBL7972055 | 0.86 | PDPK1 (0.44) | KDRGSK3BLRRK2PDPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |