Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9801352 | 0.83 | SIGMAR1 (0.36) | SIGMAR1TMEM97ALDH1A1KDM4E | |
| SCHEMBL14488147 | 0.81 | SIGMAR1 (0.35) | SIGMAR1TMEM97ALDH1A1KDM4E | |
| SCHEMBL7380009 | 0.79 | SIGMAR1 (0.35) | SIGMAR1TMEM97ALDH1A1EPHA2KDR | |
| SCHEMBL18931313 | 0.75 | — | — | |
| SCHEMBL20866118 | 0.75 | — | — | |
| SCHEMBL16576610 | 0.75 | SLC18A2 (0.36) | SIGMAR1TMEM97GAAALDH1A1LMNA | |
| SCHEMBL329848 | 0.73 | SIGMAR1 (0.33) | SIGMAR1TMEM97 | |
| SCHEMBL9801669 | 0.73 | SIGMAR1 (0.35) | SIGMAR1 | |
| Ammonia Solution, Strong SCHEMBL25437837 | 0.72 | SIGMAR1 (0.36) | SIGMAR1TMEM97ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL278051 | 0.71 | SIGMAR1 (0.50) | SIGMAR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117283-A2 | QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |