Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.54 |
| ▸ | FNTA | P49354 | 2/20 | 0.44 |
| ▸ | FNTB | P49356 | 2/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970032 | 0.88 | CYP19A1 (0.57) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL6490398 | 0.79 | MAOB (0.55) | CYP19A1CYP11B1CYP11B2MAOB | |
| SCHEMBL3499432 | 0.78 | FNTA (0.69) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL27001729 | 0.78 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2PTGDR2 | |
| Hydrochloric Acid SCHEMBL7970989 | 0.78 | FNTA (0.68) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL7984618 | 0.75 | FNTA (0.41) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL7988111 | 0.75 | CYP19A1 (0.51) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL7983941 | 0.74 | MAOB (0.47) | CYP19A1CYP11B1CYP11B2PTGDR2HPGD | |
| SCHEMBL7944912 | 0.74 | TSHR (0.39) | MMP13HPGDTSHRHSD17B10 | |
| SCHEMBL2036343 | 0.73 | CYP19A1 (0.57) | CYP19A1CYP11B1CYP11B2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |