Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.59 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326256 | 0.83 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5964482 | 0.83 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8325842 | 0.82 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8326260 | 0.80 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3616599 | 0.79 | SLC22A12 (0.49) | SLC22A12 | |
| SCHEMBL7984640 | 0.79 | SLC22A12 (0.61) | SLC22A12 | |
| SCHEMBL7970829 | 0.78 | SLC22A12 (0.47) | SLC22A12 | |
| SCHEMBL3604440 | 0.78 | SLC22A12 (0.43) | SLC22A12 | |
| SCHEMBL7981992 | 0.77 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1554109 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |