Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14193180 | 0.87 | HRH1 (0.55) | HRH1L3MBTL1SYKMAOAMAOB | |
| Hydrochloric Acid SCHEMBL3251435 | 0.85 | HRH1 (0.53) | HRH1L3MBTL1SYKMAOAMAOB | |
| SCHEMBL6794320 | 0.85 | L3MBTL1 (0.57) | HRH1L3MBTL1SYKMAOAMAOB | |
| SCHEMBL3999395 | 0.84 | HRH1 (0.51) | HRH1L3MBTL1SYKMAOAMAOB | |
| SCHEMBL11327558 | 0.82 | HRH1 (0.57) | HRH1L3MBTL1MAOAMAOBCYP1A2 | |
| SCHEMBL18343654 | 0.81 | SYK (0.55) | HRH1L3MBTL1SYKMAOAMAOB | |
| SCHEMBL17672974 | 0.80 | LMNA (0.46) | HRH1CYP1A2CYP2D6HRH3ALDH1A1 | |
| SCHEMBL11319599 | 0.80 | NPC1 (0.50) | HRH1SYKCYP1A2CYP2D6CYP2E1 | |
| Ammonia Solution, Strong SCHEMBL4843625 | 0.80 | HRH1 (0.50) | HRH1L3MBTL1SYKMAOAMAOB | |
| SCHEMBL23453426 | 0.79 | HRH1 (0.57) | HRH1L3MBTL1SYKMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001077077-A1 | SUBSTITUTED (HETERO)ARYL CARBOXAMIDE DERIVATIVES AS MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) AND APOLIPOPROTEIN B (APO B) SECRETION | NOVARTIS AG (CH) | 2001-10-18 | — | — | WO | disclosed |