SCHEMBL7984874

SCHEMBL7984874

Nc1nc(OCC2C=CCCC2)c2[nH]cnc2n1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 18/20 0.66
CCNB1 P14635 18/20 0.66
CCNA2 P20248 17/20 0.66
CDK2 P24941 17/20 0.66
CCNA1 P78396 17/20 0.66
PIN1 Q13526 3/20 0.65
CCNB2 O95067 1/20 0.65
MAPK3 P27361 1/20 0.65
CLK1 P49759 1/20 0.65
CDK5 Q00535 1/20 0.65
CCNB3 Q8WWL7 1/20 0.65
MAP3K5 Q99683 1/20 0.65
MGMT P16455 8/20 0.53
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
NFKB1 P19838 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7984872 0.81 CDK2 (0.42) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6266042 0.80 CDK2 (1.00) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL3462331 0.79 CDK2 (1.00) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6267558 0.77 CDK1 (1.00) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL9682544 0.77 CDK1 (0.63) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL8069356 0.76 CDK1 (0.69) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6268104 0.72 CDK1 (1.00) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL7982278 0.71 CDK1 (0.62) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL7981110 0.71 CDK1 (0.62) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL30176198 0.70 CDK1 (0.77) CDK1CCNB1CCNA2CDK2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US disclosed