Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 18/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 18/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 17/20 | 0.63 |
| ▸ | CDK2 | P24941 | 17/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 17/20 | 0.63 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.61 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.61 |
| ▸ | MGMT | P16455 | 6/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619367 | 0.79 | CDK1 (0.66) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL6266042 | 0.77 | CDK2 (1.00) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL7984874 | 0.77 | CDK1 (0.66) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL8830357 | 0.77 | CDK2 (0.40) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL3462331 | 0.76 | CDK2 (1.00) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| Methylguanine SCHEMBL231097 | 0.74 | CDK1 (0.69) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| Methylguanine SCHEMBL29903462 | 0.74 | CDK1 (0.69) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL6268104 | 0.74 | CDK1 (1.00) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL8939264 | 0.74 | CDK1 (0.62) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL159110 | 0.73 | PDPK1 (0.50) | CDK1CCNB1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153318-A | Viricides for hepatitis and human t-cell leukemia/lymphoma viruses | BURROUGHS WELLCOME CO. (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0421739-A1 | 3'-azido purine nucleoside | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-04-10 | — | — | EP | disclosed |