Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 17/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479790 | 1.00 | OPRK1 (0.78) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 | |
| SCHEMBL6479796 | 1.00 | OPRK1 (0.78) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 | |
| SCHEMBL5630305 | 0.88 | OPRK1 (0.82) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 | |
| SCHEMBL5629262 | 0.88 | OPRK1 (1.00) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 | |
| SCHEMBL8459482 | 0.88 | OPRK1 (1.00) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 | |
| SCHEMBL6480069 | 0.85 | OPRK1 (0.76) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL7722061 | 0.85 | OPRK1 (0.76) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL6479482 | 0.85 | OPRK1 (0.76) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL10434997 | 0.83 | OPRK1 (0.86) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 | |
| SCHEMBL10434613 | 0.83 | OPRK1 (0.82) | OPRK1CYP2D6SIGMAR1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239154-B1 | ARYLACETAMIDES, AGONISTS AT KAPPA OPIOID RECEPTORS. | ADOLOR CORPORATION | 2001-05-29 | — | — | US | disclosed |
| US-6057323-A | PIPERAZINE DERIVATIVES | ADOLOR CORPORATION (US) | 2000-05-02 | — | — | US | disclosed |