Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 17/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5629262 | 1.00 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL10434997 | 0.93 | OPRK1 (0.86) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL10434613 | 0.90 | OPRK1 (0.82) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL5630305 | 0.90 | OPRK1 (0.82) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL7985237 | 0.88 | OPRK1 (0.78) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL6479796 | 0.88 | OPRK1 (0.78) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL6479790 | 0.88 | OPRK1 (0.78) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL5629630 | 0.87 | OPRK1 (0.77) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL10434844 | 0.87 | OPRK1 (0.76) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL6360245 | 0.86 | OPRK1 (0.75) | OPRK1CYP2D6OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981513-A | ADMINISTERING ANTI-PRUITIC COMPOUNDS TO PATIENTS | ADOLOR CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |