SCHEMBL798537

SCHEMBL798537

COc1cccc(Nc2c(O)nc(N)nc2O)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.59
RAB9A P51151 3/20 0.59
POLB P06746 2/20 0.59
ROCK1 Q13464 1/20 0.57
MEN1 O00255 6/20 0.56
KMT2A Q03164 6/20 0.56
RAPGEF4 Q8WZA2 1/20 0.54
MAPT P10636 3/20 0.53
MAPK1 P28482 1/20 0.53
IDO1 P14902 1/20 0.51
EGFR P00533 2/20 0.49
PDGFRB P09619 1/20 0.49
KDR P35968 1/20 0.49
GFER P55789 2/20 0.48
TSHR P16473 1/20 0.48
KCNH3 Q9ULD8 1/20 0.48
PDE4B Q07343 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1694246 0.76 MAPT (0.49) NPC1RAB9APOLBROCK1MEN1
SCHEMBL28736260 0.75 POLB (0.68) NPC1RAB9APOLBROCK1MEN1
SCHEMBL28736338 0.75 ROCK1 (0.67) NPC1RAB9APOLBROCK1MEN1
SCHEMBL29609014 0.75 ROCK1 (0.67) NPC1RAB9APOLBROCK1MEN1
SCHEMBL20355235 0.75 RAB9A (0.72) NPC1RAB9APOLBROCK1MEN1
SCHEMBL654352 0.75 TSHR (0.63) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL1085867 0.75 MEN1 (0.71) NPC1RAB9APOLBROCK1MEN1
SCHEMBL29609310 0.74 MAPT (0.72) NPC1RAB9APOLBROCK1MEN1
SCHEMBL28736243 0.74 MAPT (0.72) NPC1RAB9APOLBROCK1MEN1
SCHEMBL13302353 0.73 MEN1 (0.69) NPC1RAB9APOLBROCK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616077-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2013-07-24 EP disclosed
EP-2575969-A1 ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2013-04-10 EP disclosed
WO-2012035423-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2012-03-22 WO disclosed
EP-2405973-A2 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2012-01-18 EP disclosed
WO-2011147753-A1 ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) 2011-12-01 WO disclosed
WO-2010103130-A2 NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) 2010-09-16 WO disclosed