SCHEMBL7985522

SCHEMBL7985522

O=C(Nc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2)cc1)OCc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.59
MAOA P21397 2/20 0.59
MAOB P27338 2/20 0.59
SMN1; SMN2 Q16637 3/20 0.58
HRH3 Q9Y5N1 2/20 0.58
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58
RCOR1 Q9UKL0 2/20 0.58
ENPP2 Q13822 1/20 0.57
CYP2C19 P33261 1/20 0.56
TGM2 P21980 3/20 0.54
CCR1 P32246 1/20 0.54
GRIN2B Q13224 2/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
F13A1 P00488 2/20 0.52
TGM1 P22735 2/20 0.52
POLB P06746 1/20 0.51
HTT P42858 1/20 0.51
CHRM4 P08173 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14824682 0.89 NAMPT (0.65) KDM1AMAOAMAOBSMN1; SMN2HRH3
SCHEMBL4035554 0.86 SMN1; SMN2 (0.72) SMN1; SMN2NPC1RAB9AENPP2CYP2C19
SCHEMBL6749001 0.85 SMN1; SMN2 (0.67) SMN1; SMN2NPC1RAB9ACYP2C19CCR1
SCHEMBL8010255 0.84 HRH3 (0.59) KDM1AMAOAMAOBHRH3RCOR1
SCHEMBL25329767 0.83 SMN1; SMN2 (0.64) SMN1; SMN2NPC1RAB9AENPP2CYP2C19
SCHEMBL15747803 0.83 SMN1; SMN2 (0.64) SMN1; SMN2NPC1RAB9ACYP2C19CCR1
SCHEMBL15531061 0.83 ENPP2 (0.59) KDM1ASMN1; SMN2NPC1RAB9ARCOR1
SCHEMBL15379737 0.82 ENPP2 (0.64) SMN1; SMN2NPC1RAB9AENPP2CYP2C19
SCHEMBL7503285 0.82 SMN1; SMN2 (0.62) SMN1; SMN2HRH3NPC1RAB9ACYP2C19
SCHEMBL6745783 0.82 SMN1; SMN2 (0.62) SMN1; SMN2NPC1RAB9AENPP2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313307-B1 DEBLOCKING, DEPROTECTING; CATALYTIC HYDROGENATION, ALKYLATION; PREPARING MICROBIOCIDES AGAINST STAPHYLOCOCCUS, STREPTOCOCCUS, MYCOBACTERIUM, AND CLOSTRIDIUM PHARMACIA & UPJOHN COMPANY 2001-11-06 US disclosed