Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.42 |
| ▸ | PTPRB | P23467 | 3/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | PTPRE | P23469 | 2/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14734449 | 0.79 | KDM5B (0.58) | KDM5BKDM4EALDH1A1KDM4CMAPT | |
| SCHEMBL3574223 | 0.78 | KDM5B (0.57) | KDM5BPTPN1KDM4EALDH1A1KDM4C | |
| SCHEMBL7847175 | 0.75 | DHODH (0.60) | KDM4EALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL28309875 | 0.75 | KDM5B (0.54) | KDM5BKDM4EALDH1A1KDM4CMAPT | |
| SCHEMBL30616877 | 0.74 | ATR (0.48) | KDM5BALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5769273 | 0.69 | KDM4E (0.52) | KDM5BKDM4EALDH1A1KDM4CMAPT | |
| SCHEMBL161825 | 0.69 | KDM5B (0.46) | KDM5BKDM4EALDH1A1KDM4CMAPT | |
| SCHEMBL4769775 | 0.69 | KDM5B (0.46) | KDM5BKDM4EALDH1A1KDM4CMAPT | |
| SCHEMBL7850234 | 0.68 | KDM4E (0.41) | PTPN1PTPN2PTPRBPTPN6KDM4E | |
| SCHEMBL7991807 | 0.68 | KDM4C (0.64) | KDM5BPTPN1KDM4EALDH1A1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |