Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.64 |
| ▸ | PDE4A | P27815 | 11/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.64 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542303 | 0.84 | GFER (0.48) | PDE4DPDE4BPDE4APDE4CGFER | |
| SCHEMBL7110388 | 0.83 | PDE4D (0.64) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7361851 | 0.81 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.79 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7431497 | 0.79 | CA12 (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL70770 | 0.78 | PDE4D (0.80) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| Piclamilast SCHEMBL26573 | 0.78 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7335658 | 0.78 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7338627 | 0.78 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7338639 | 0.78 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652868-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1995-05-17 | — | — | EP | claimed |
| WO-1994002465-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1994-02-03 | — | — | WO | claimed |
| US-6255326-B1 | ANTIINFLAMMATORY AGENT; AUTOIMMUNE DISEASES | AVENTIS PHARMA LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |
| US-6096768-A | ADMINISTERING A 3, 5, 6-SUBSTITUTED PHENYL COMPOUND FOR THE TREATMENT OF INFLAMMATION AND AUTOIMMUNE DISORDERS | RHONE-POULENC RORER LIMITED (GB) | 2000-08-01 | — | — | US | disclosed |
| EP-0652868-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994002465-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |