Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.44 |
| ▸ | PDE4A | P27815 | 12/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985943 | 0.84 | PDE4D (0.64) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL15532207 | 0.79 | PDE4B (0.69) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL9526223 | 0.78 | PDE4B (0.68) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7474586 | 0.70 | PDE4B (0.50) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7425561 | 0.70 | PDE4B (0.50) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7985937 | 0.70 | PDE4B (0.35) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7417915 | 0.70 | PDE4B (0.52) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7107092 | 0.69 | PDE4D (0.39) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5083406 | 0.67 | PDE4D (0.45) | GFERPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL30614148 | 0.66 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | claimed |
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| US-5840724-A | COMPOUNDS FOR TUMOR NECROSIS FACTOR OR ENZYME INHIBITORS OF PHOSPHODIESTERASES | RHONE-POULENC RORER LIMITED (GB) | 1998-11-24 | — | — | US | disclosed |
| US-5698711-A | INHIBITORS OF TUMOR NECROSIS FACTOR, CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE AND EOSINOPHILS | RHONE-POULENC RORER LIMITED (GB) | 1997-12-16 | — | — | US | disclosed |
| US-5679696-A | FOR INHIBITING TUMOR NECROSIS FACTOR; ENZYME INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1997-10-21 | — | — | US | disclosed |