Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974861 | 0.83 | SMN1; SMN2 (0.51) | KDM4ESMN1; SMN2TDP1ALDH1A1CA12 | |
| SCHEMBL7989125 | 0.78 | CA9 (0.59) | ALDH1A1PKMCA12CA1CA2 | |
| SCHEMBL7986767 | 0.77 | PTGS2 (0.57) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL5931251 | 0.74 | SMN1; SMN2 (0.69) | KDM4ESMN1; SMN2DHFRTSHRTDP1 | |
| SCHEMBL7985179 | 0.74 | POLB (0.62) | SMN1; SMN2TSHRTDP1ALDH1A1POLB | |
| SCHEMBL7985913 | 0.73 | KAT8 (0.55) | KDM4ESMN1; SMN2ALDH1A1POLBCA1 | |
| SCHEMBL28687948 | 0.72 | SMN1; SMN2 (0.67) | KDM4ESMN1; SMN2DHFRTSHRTDP1 | |
| SCHEMBL4613423 | 0.71 | KDM4E (0.67) | KDM4ESMN1; SMN2DHFRTSHRTDP1 | |
| SCHEMBL6736416 | 0.70 | KMT2A (0.49) | KDM4ESMN1; SMN2TDP1ALDH1A1POLB | |
| SCHEMBL9325215 | 0.70 | KDM4E (0.57) | KDM4ESMN1; SMN2DHFRTSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | claimed |
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | disclosed |
| US-6180628-B1 | PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES | VIROPHARMA INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |