Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.57 |
| ▸ | CA1 | P00915 | 10/20 | 0.56 |
| ▸ | CA2 | P00918 | 10/20 | 0.56 |
| ▸ | CA9 | Q16790 | 10/20 | 0.56 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974861 | 0.81 | SMN1; SMN2 (0.51) | PTGS2CA1CA2CA9KAT8 | |
| SCHEMBL7989367 | 0.80 | PTGS2 (0.43) | PTGS2CA1CA2CA9KAT8 | |
| SCHEMBL6736416 | 0.77 | KMT2A (0.49) | PTGS2KAT8MEN1MAPTMAPK1 | |
| SCHEMBL7989125 | 0.77 | CA9 (0.59) | CA1CA2CA9CA12MEN1 | |
| SCHEMBL7986048 | 0.77 | KDM4E (0.54) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL7985913 | 0.76 | KAT8 (0.55) | CA1CA2CA9KAT8MEN1 | |
| SCHEMBL418903 | 0.75 | PTGS2 (0.68) | PTGS2CA1CA2CA9KAT8 | |
| SCHEMBL443915 | 0.75 | PTGS2 (0.68) | PTGS2CA1CA2CA9KAT8 | |
| SCHEMBL29517963 | 0.75 | PTGS2 (0.67) | PTGS2CA1CA2CA9KAT8 | |
| SCHEMBL443916 | 0.75 | PTGS2 (0.68) | PTGS2CA1CA2CA9KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | disclosed |
| US-6180628-B1 | PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES | VIROPHARMA INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | disclosed |