SCHEMBL7986065

SCHEMBL7986065

CCOC(=O)Cc1cc2c(s1)CCN(C(=O)[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)OC(C)(C)C)C2

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.51
KMT2A Q03164 3/20 0.41
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
MAPK1 P28482 1/20 0.39
HCRTR2 O43614 2/20 0.38
P2RX7 Q99572 5/20 0.38
PABPC1 P11940 1/20 0.37
HRH2 P25021 2/20 0.37
HRH1 P35367 2/20 0.37
PTPRB P23467 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7986071 0.92 ADORA1 (0.52) ADORA1KMT2AMAPK1HCRTR2P2RX7
SCHEMBL7992666 0.91 ADORA1 (0.56) ADORA1KMT2AMAPK1HCRTR2P2RX7
SCHEMBL7992050 0.91 ADORA1 (0.52) ADORA1KMT2AMAPK1HCRTR2HRH2
SCHEMBL7975232 0.89 ADORA1 (0.51) ADORA1KMT2AP2RX7HRH2HRH1
SCHEMBL7985559 0.88 ADORA1 (0.50) ADORA1KMT2APPARGPPARAMAPK1
SCHEMBL7985657 0.88 ADORA1 (0.50) ADORA1KMT2AMAPK1HCRTR2P2RX7
SCHEMBL7975386 0.87 ADORA1 (0.53) ADORA1KMT2AMAPK1HCRTR2PABPC1
SCHEMBL7986565 0.86 ADORA1 (0.55) ADORA1KMT2AP2RX7HRH2HRH1
Trifluoroacetic Acid SCHEMBL7986493 0.86 ITGB3 (0.49) ADORA1KMT2AHCRTR2P2RX7
SCHEMBL7992607 0.85 ADORA1 (0.46) ADORA1KMT2AP2RX7PABPC1PTPRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed