Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.86 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CCNC | P24863 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | STK25 | O00506 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28393 | 0.93 | SIGMAR1 (1.00) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| SCHEMBL894920 | 0.93 | SIGMAR1 (1.00) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| SCHEMBL9644712 | 0.91 | SIGMAR1 (0.96) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| Piperazine SCHEMBL28228981 | 0.91 | SIGMAR1 (0.96) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| Hydrochloric Acid SCHEMBL1597474 | 0.91 | SIGMAR1 (0.96) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| Piperazine SCHEMBL27760905 | 0.89 | SIGMAR1 (0.93) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| SCHEMBL3423662 | 0.86 | SIGMAR1 (0.86) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| SCHEMBL12344755 | 0.85 | SIGMAR1 (0.83) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| Tert-Butyl Formate SCHEMBL27710034 | 0.84 | SIGMAR1 (0.69) | SIGMAR1HPGDCCNCCDK8RXFP1 | |
| Nitric Acid SCHEMBL14695754 | 0.83 | SIGMAR1 (0.81) | SIGMAR1HPGDCCNCCDK8RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1223659-A | Fused imidazopyridine derivatives as antihyperlipidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |