SCHEMBL7986391

SCHEMBL7986391

CCCCS(=O)(=O)Nc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N2CCc3sc(CC(=O)OCC)cc3C2)cc1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 2/20 0.47
PTPRB P23467 5/20 0.41
KMT2A Q03164 2/20 0.36
HRH2 P25021 2/20 0.36
HRH1 P35367 2/20 0.36
P2RX7 Q99572 2/20 0.35
NPR3 P17342 2/20 0.35
PABPC1 P11940 1/20 0.35
NAMPT P43490 1/20 0.34
ITGB3 P05106 1/20 0.34
ITGB1 P05556 1/20 0.34
ITGAV P06756 1/20 0.34
ITGA2B P08514 1/20 0.34
ITGB5 P18084 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7985657 0.91 ADORA1 (0.50) ADORA1PTPRBKMT2AP2RX7PABPC1
SCHEMBL7975784 0.90 ADORA1 (0.53) ADORA1PTPRBKMT2AHRH2HRH1
SCHEMBL7985627 0.88 ADORA1 (0.52) ADORA1PTPRBKMT2AP2RX7PABPC1
SCHEMBL7992607 0.87 ADORA1 (0.46) ADORA1PTPRBKMT2AP2RX7PABPC1
SCHEMBL7992666 0.86 ADORA1 (0.56) ADORA1PTPRBKMT2AHRH2HRH1
SCHEMBL7986071 0.86 ADORA1 (0.52) ADORA1PTPRBKMT2AP2RX7PABPC1
SCHEMBL7992676 0.86 ITGB3 (0.47) KMT2AITGB3ITGA2B
SCHEMBL7986490 0.86 ADORA1 (0.37) ADORA1PTPRBKMT2AHRH2HRH1
Trifluoroacetic Acid SCHEMBL7985418 0.85 ITGB3 (0.44) ADORA1KMT2AITGB3ITGA2B
SCHEMBL7986065 0.85 ADORA1 (0.51) ADORA1PTPRBKMT2AHRH2HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed