Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997902 | 0.85 | LIMK2 (0.51) | LIMK2GPR119HPGDKDM4EPKM | |
| SCHEMBL6403145 | 0.84 | KDM4E (0.43) | LIMK2GPR119HPGDKDM4EPKM | |
| SCHEMBL1401260 | 0.84 | HPGD (0.53) | LIMK2GPR119HPGDKDM4EPKM | |
| SCHEMBL5570674 | 0.83 | HPGD (0.51) | LIMK2GPR119HPGDKDM4EPKM | |
| SCHEMBL30085213 | 0.80 | KDM4E (0.48) | LIMK2GPR119HPGDKDM4EPKM | |
| SCHEMBL2424909 | 0.79 | HPGD (0.48) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL25580911 | 0.79 | HPGD (0.48) | LIMK2GPR119HPGDKDM4EPKM | |
| SCHEMBL22318555 | 0.78 | CTSK (0.36) | HPGD | |
| SCHEMBL22318556 | 0.78 | CTSK (0.36) | HPGD | |
| SCHEMBL27391556 | 0.78 | HPGD (0.50) | LIMK2GPR119HPGDKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |