SCHEMBL7986545

SCHEMBL7986545

CC(C)(C)c1ccc(CC2=NCCN2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 10/20 1.00
HTR1B P28222 7/20 1.00
ADRA1A P35348 5/20 1.00
ADRA2A P08913 4/20 1.00
ADRA2B P18089 4/20 1.00
ADRA2C P18825 4/20 1.00
ADRA1D P25100 4/20 1.00
ADRA1B P35368 4/20 1.00
TAAR1 Q96RJ0 4/20 0.62
CYP2D6 P10635 3/20 0.62
LMNA P02545 2/20 0.62
TSHR P16473 2/20 0.62
CYP1A2 P05177 1/20 0.62
HTR1A P08908 2/20 0.60
TP53 P04637 1/20 0.60
CHRM2 P08172 1/20 0.60
CHRM1 P11229 1/20 0.60
DRD2 P14416 1/20 0.60
CHRM3 P20309 1/20 0.60
HTR2A P28223 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7983686 0.98 HTR1D (0.97) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL27112920 0.81 HTR1D (0.68) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL5198365 0.79 HTR1D (0.65) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL4037274 0.79 HTR1D (0.71) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL7980206 0.78 HTR1D (1.00) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL953972 0.77 RAD52 (0.82) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL2869241 0.77 HTR1D (0.69) HTR1DHTR1BADRA1AADRA2AADRA2B
SCHEMBL9393147 0.77 HTR1D (0.69) HTR1DHTR1BADRA1AADRA2AADRA2B
Hydrochloric Acid SCHEMBL7982769 0.77 HTR1D (0.97) HTR1DHTR1BADRA1AADRA2AADRA2B
Tolazoline SCHEMBL34961 0.77 TAAR1 (1.00) HTR1DHTR1BADRA1AADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6048862-A Benzylamidine derivatives with serotonin receptor binding activity VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-04-11 US claimed
WO-1998012183-A1 IMIDAZOLES WITH SEROTONIN RECEPTOR BINDING ACTIVITY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1998-03-26 WO claimed
US-6288101-B1 ADMINISTERING COMPOUNDS SUCH AS 2,6-DIMETHYL-4-ISOPROPYLBENZALDEHYDE TO TREAT INDICATIONS WHERE STIMULATION OF SUBTYPES OF THE SEROTONIN RECEPTOR IS IMPLICATED, SUCH AS MIGRAINES VIRGINIA COMMONWEALTH UNIVERSITY 2001-09-11 US disclosed
US-6124338-A TREATING MIGRAINE HEADACHE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-09-26 US disclosed
US-6048862-A Benzylamidine derivatives with serotonin receptor binding activity VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-04-11 US disclosed
US-5969137-A TREATMENT OF NERVOUS SYSTEM DISORDERS VIRGINIA COMMONWEALTH UNIVERSITY (US) 1999-10-19 US disclosed
WO-1998012183-A1 IMIDAZOLES WITH SEROTONIN RECEPTOR BINDING ACTIVITY ALLELIX BIOPHARMACEUTICALS INC. (CA) 1998-03-26 WO disclosed