Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035766 | 0.89 | PTGS1 (0.59) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11410387 | 0.88 | PTGS1 (0.58) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL7990464 | 0.86 | MAPK9 (0.54) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL7989783 | 0.85 | MAPK9 (0.51) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL7987319 | 0.82 | MAPK1 (0.50) | PTGS1PTGS2HPGDKMT2AMAPK9 | |
| SCHEMBL7986653 | 0.81 | PTGS1 (0.51) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL9220209 | 0.81 | PTGS1 (0.81) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL805663 | 0.81 | PTGS1 (0.81) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL7976072 | 0.81 | MAPK9 (0.52) | PTGS1PTGS2HPGDKMT2AMEN1 | |
| SCHEMBL24893823 | 0.79 | PTGS1 (0.52) | PTGS1PTGS2HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |