Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549622 | 0.92 | KDR (0.55) | CNR2KDRHTR6FLT3FLT1 | |
| SCHEMBL7555811 | 0.91 | KDR (0.50) | CNR2KDRHTR6FLT3PRKD1 | |
| SCHEMBL7994193 | 0.87 | KDR (0.49) | CNR2KDRHTR6FLT3FYN | |
| SCHEMBL7990971 | 0.86 | KDR (0.70) | CNR2KDRHTR6FLT3FLT1 | |
| SCHEMBL7549158 | 0.85 | KDR (0.69) | KDRHTR6FLT3PRKD1TDP1 | |
| SCHEMBL7549404 | 0.84 | KDR (0.51) | CNR2KDRFLT1FLT4GSK3B | |
| SCHEMBL7554297 | 0.84 | KDR (0.54) | CNR2KDRFLT1FLT4GSK3B | |
| SCHEMBL7545417 | 0.83 | KDR (0.52) | CNR2KDRHTR6CYP11B1CYP11B2 | |
| SCHEMBL7990876 | 0.82 | KDR (0.56) | KDRHTR6FLT3PRKD1TDP1 | |
| SCHEMBL7549676 | 0.82 | KDR (0.50) | CNR2KDRFLT3FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |