Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | QPCT | Q16769 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549676 | 0.94 | KDR (0.50) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7554297 | 0.93 | KDR (0.54) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7550389 | 0.93 | KDR (0.55) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7555367 | 0.92 | KDR (0.51) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7554716 | 0.92 | KDR (0.51) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7553648 | 0.88 | KDR (0.50) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7551199 | 0.87 | KDR (0.54) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7993934 | 0.87 | KDR (0.70) | KDRFLT1FLT4CNR2HRH3 | |
| SCHEMBL7987655 | 0.86 | KDR (0.51) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7554271 | 0.86 | KDR (0.49) | KDRFLT1FLT4CNR2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |