Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | FLT4 | P35916 | 3/20 | 0.51 |
| ▸ | GSK3B | P49841 | 6/20 | 0.43 |
| ▸ | QPCT | Q16769 | 6/20 | 0.43 |
| ▸ | HTR3A | P46098 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986847 | 0.94 | KDR (0.50) | KDRFLT1FLT4HTR3ACHRNB1 | |
| SCHEMBL7551398 | 0.93 | KDR (0.54) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7986865 | 0.91 | KDR (0.50) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7556924 | 0.89 | KDR (0.59) | KDRFLT1FLT4GSK3BHRH3 | |
| SCHEMBL7987168 | 0.88 | KDR (0.54) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7990494 | 0.86 | KDR (0.51) | KDRFLT1FLT4GSK3B | |
| SCHEMBL7554266 | 0.86 | KDR (0.69) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7551471 | 0.85 | KDR (0.49) | KDRFLT1FLT4HRH3CHRNB1 | |
| SCHEMBL7549825 | 0.84 | KDR (0.51) | KDRGSK3BQPCT | |
| SCHEMBL7550710 | 0.84 | KDR (0.52) | KDRFLT1FLT4GSK3BQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |