Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | STK4 | Q13043 | 1/20 | 0.32 |
| ▸ | STK3 | Q13188 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548486 | 0.92 | KDR (0.41) | KDRFLT1FLT4GRIN2BGRIN1 | |
| SCHEMBL7986476 | 0.91 | KDR (0.39) | KDRFLT1FLT4 | |
| SCHEMBL7990817 | 0.89 | KDR (0.36) | KDRFLT1FLT4GRIN2BGRIN1 | |
| SCHEMBL7549609 | 0.87 | KDR (0.49) | KDRFLT1FLT4GRIN2BTAAR1 | |
| SCHEMBL7553622 | 0.85 | KDR (0.55) | KDRFLT1FLT4 | |
| SCHEMBL7986664 | 0.85 | MAOB (0.40) | KDRFLT1FLT4 | |
| SCHEMBL7994139 | 0.85 | KDR (0.41) | KDRFLT1FLT4GRIN2BTAAR1 | |
| SCHEMBL7988607 | 0.85 | KDR (0.43) | KDRFLT1FLT4GRIN2BTAAR1 | |
| SCHEMBL7504511 | 0.84 | KDR (0.54) | KDRFLT1FLT4GRIN2BTAAR1 | |
| SCHEMBL7990227 | 0.80 | PDE4B (0.45) | KDRFLT1FLT4GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |