Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986664 | 0.92 | MAOB (0.40) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7986898 | 0.89 | KDR (0.38) | KDRFLT1FLT4MAPTGRIN1 | |
| SCHEMBL7548486 | 0.88 | KDR (0.41) | KDRFLT1FLT4GRIN1GRIN2B | |
| SCHEMBL7546221 | 0.86 | KDR (0.48) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7986476 | 0.85 | KDR (0.39) | KDRFLT1FLT4 | |
| SCHEMBL7552915 | 0.85 | KDR (0.51) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7976435 | 0.84 | PRKCA (0.42) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7550632 | 0.84 | PDE4B (0.43) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7553622 | 0.82 | KDR (0.55) | KDRFLT1FLT4CYP3A4CYP2C9 | |
| SCHEMBL7990227 | 0.81 | PDE4B (0.45) | KDRFLT1FLT4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |