Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990817 | 0.92 | KDR (0.36) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7986476 | 0.90 | KDR (0.39) | KDRFLT1FLT4MAP4K4CHRNB1 | |
| SCHEMBL7548486 | 0.89 | KDR (0.41) | KDRFLT1FLT4PLA2G4A | |
| SCHEMBL7986898 | 0.85 | KDR (0.38) | KDRFLT1FLT4 | |
| SCHEMBL7551047 | 0.85 | KDR (0.51) | MAOBKDRFLT1FLT4CYP11B1 | |
| SCHEMBL7572831 | 0.85 | MAOB (0.39) | MAOBKDRCYP11B1CYP11B2MAP4K4 | |
| SCHEMBL7550587 | 0.84 | KDR (0.49) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7553622 | 0.83 | KDR (0.55) | KDRFLT1FLT4CYP3A4CYP2C9 | |
| SCHEMBL7990418 | 0.82 | KDR (0.39) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7549809 | 0.81 | HTR6 (0.43) | KDRFLT1FLT4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |