Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993650 | 0.91 | EDNRA (0.49) | EDNRAACENPC1ALDH1A1TP53 | |
| SCHEMBL7976824 | 0.87 | HPGD (0.46) | TAS1R3TAS1R1NPC1ALDH1A1TP53 | |
| SCHEMBL7993759 | 0.82 | MME (0.52) | ACEALDH1A1TSHRHPGDCTSL | |
| SCHEMBL29272959 | 0.76 | TAS1R3 (0.74) | TAS1R3TAS1R1ACENPC1ALDH1A1 | |
| SCHEMBL29272957 | 0.76 | TAS1R3 (0.74) | TAS1R3TAS1R1ACENPC1ALDH1A1 | |
| SCHEMBL7988173 | 0.75 | SMN1; SMN2 (0.53) | TP53MAPTSMN1; SMN2IL1RNERAP2 | |
| SCHEMBL7977103 | 0.75 | EDNRA (0.49) | EDNRAACENPC1ALDH1A1TP53 | |
| SCHEMBL7987574 | 0.73 | MAPK1 (0.53) | ACESMN1; SMN2 | |
| SCHEMBL7990351 | 0.73 | MAPK1 (0.53) | ACESMN1; SMN2 | |
| SCHEMBL18791071 | 0.73 | PSMB5 (0.60) | CTSKALDH1A1TSHRSMN1; SMN2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |