Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.49 |
| ▸ | ACE | P12821 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986911 | 0.91 | EDNRA (0.47) | EDNRAACEALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7993759 | 0.91 | MME (0.52) | ACEALDH1A1TSHRMMEHPGD | |
| SCHEMBL7976824 | 0.79 | HPGD (0.46) | ALDH1A1SMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL7988173 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53MAPT | |
| SCHEMBL7987574 | 0.77 | MAPK1 (0.53) | ACESMN1; SMN2 | |
| SCHEMBL7986607 | 0.77 | MAPK1 (0.53) | ACESMN1; SMN2 | |
| SCHEMBL7990351 | 0.77 | MAPK1 (0.53) | ACESMN1; SMN2 | |
| SCHEMBL7993516 | 0.76 | EDNRA (0.59) | EDNRAACEALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7987577 | 0.75 | NPC1 (0.48) | ALDH1A1TSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL7977103 | 0.74 | EDNRA (0.49) | EDNRAACEALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |