Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.70 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996204 | 0.90 | PPARG (0.79) | PPARGAGTR1AGTR2 | |
| SCHEMBL7987035 | 0.86 | PPARG (0.70) | PPARGAGTR1AGTR2TBXA2R | |
| SCHEMBL8000001 | 0.85 | PPARG (0.69) | PPARGAGTR1AGTR2 | |
| SCHEMBL7987032 | 0.81 | PPARG (0.79) | PPARGAGTR1AGTR2 | |
| SCHEMBL8040521 | 0.81 | PPARG (0.68) | PPARGAGTR1AGTR2TBXA2R | |
| SCHEMBL7999940 | 0.78 | PPARG (0.70) | PPARGAGTR1AGTR2TBXA2R | |
| SCHEMBL7986953 | 0.77 | PPARG (0.69) | PPARGAGTR1AGTR2 | |
| SCHEMBL6169342 | 0.77 | AGTR1 (0.62) | PPARGAGTR1AGTR2 | |
| SCHEMBL8036202 | 0.76 | PPARG (0.65) | PPARGAGTR1AGTR2TBXA2R | |
| SCHEMBL9192299 | 0.76 | AGTR1 (1.00) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | claimed |
| EP-0830343-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | claimed |
| WO-1996039390-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | claimed |
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| EP-0830343-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039390-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |