Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.70 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987035 | 0.92 | PPARG (0.70) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL7986953 | 0.91 | PPARG (0.69) | PPARGAGTR1AGTR2 | |
| SCHEMBL7987032 | 0.90 | PPARG (0.79) | PPARGAGTR1AGTR2 | |
| SCHEMBL9201172 | 0.86 | DRD2 (0.78) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8000001 | 0.83 | PPARG (0.69) | PPARGAGTR1AGTR2 | |
| SCHEMBL6168561 | 0.82 | AGTR1 (0.76) | PPARGAGTR1AGTR2 | |
| SCHEMBL7996204 | 0.81 | PPARG (0.79) | PPARGAGTR1AGTR2 | |
| SCHEMBL6170958 | 0.81 | AGTR1 (0.62) | PPARGAGTR1AGTR2 | |
| SCHEMBL9275378 | 0.80 | AGTR1 (0.78) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL7673045 | 0.80 | AGTR1 (0.60) | AGTR1AGTR2DRD2TBXA2RTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| EP-0830343-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039390-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |