Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420106 | 0.85 | PDE10A (0.59) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL12169115 | 0.78 | PDE10A (0.59) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL1419989 | 0.77 | PDE10A (0.58) | PDE10A | |
| SCHEMBL8007284 | 0.76 | FFAR1 (0.38) | PDE10ACYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL28002003 | 0.73 | MEN1 (0.55) | PDE10AMEN1KMT2ACYSLTR1CYSLTR2 | |
| SCHEMBL1557935 | 0.71 | PTGS1 (0.53) | PDE10AMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL12169108 | 0.71 | PDE10A (0.55) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL1420404 | 0.70 | GPBAR1 (0.52) | PDE10ACYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL3328309 | 0.69 | PDE10A (0.56) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL1420352 | 0.69 | PDE10A (0.57) | PDE10ACYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158393-A1 | 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |