Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29195616 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL30846014 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL2184004 | 0.72 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL9172908 | 0.72 | NOTUM (0.47) | ALDH1A1RAB9AKMT2A | |
| SCHEMBL6381049 | 0.72 | TDP1 (0.48) | SMN1; SMN2HPGDHSD17B10KMT2AASAH1 | |
| SCHEMBL8013907 | 0.72 | TDP1 (0.52) | SMN1; SMN2HPGDHSD17B10KMT2AEGLN3 | |
| SCHEMBL273486 | 0.72 | TDP1 (0.52) | SMN1; SMN2HPGDHSD17B10KMT2AFGFR1 | |
| SCHEMBL6738639 | 0.70 | POLB (0.46) | SMN1; SMN2ALDH1A1RAB9AAPAF1KMT2A | |
| SCHEMBL1879818 | 0.69 | HTT (0.48) | SMN1; SMN2HPGDHSD17B10KMT2AEGLN3 | |
| SCHEMBL20683088 | 0.69 | TDP1 (0.48) | SMN1; SMN2ALDH1A1HPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-5990146-A | TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-11-23 | — | — | US | disclosed |