Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.49 |
| ▸ | CDK4 | P11802 | 15/20 | 0.49 |
| ▸ | CCND1 | P24385 | 15/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 14/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987393 | 0.91 | CDK2 (0.49) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7998051 | 0.87 | CCNE2 (0.58) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7987302 | 0.86 | CDK4 (0.55) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL8003514 | 0.79 | CCNE2 (0.62) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7987389 | 0.78 | CDK4 (0.53) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL8003511 | 0.78 | CDK4 (0.56) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL5514244 | 0.77 | CCNE2 (0.73) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL5514242 | 0.75 | CCNE2 (0.78) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7998047 | 0.74 | CCNE2 (0.65) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL6352489 | 0.72 | CDK4 (0.60) | CDK2CDK4CCND1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291504-B1 | POTENT INHIBITORS OF THE CLASS OF ENZYMES KNOWN AS CYCLIN DEPENDENT KINASES | DUPONT PHARMACEUTICALS COMPANY | 2001-09-18 | — | — | US | claimed |
| US-6291504-B1 | POTENT INHIBITORS OF THE CLASS OF ENZYMES KNOWN AS CYCLIN DEPENDENT KINASES | DUPONT PHARMACEUTICALS COMPANY | 2001-09-18 | — | — | US | disclosed |