Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 1.00 |
| ▸ | PRKACA | P17612 | 3/20 | 0.65 |
| ▸ | PRKACG | P22612 | 3/20 | 0.65 |
| ▸ | PRKACB | P22694 | 3/20 | 0.65 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 5/20 | 0.43 |
| ▸ | DDO | Q99489 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984052 | 0.84 | SRC (0.71) | SRCPRKACAPRKACGPRKACBDAO | |
| SCHEMBL28853705 | 0.80 | SRC (0.67) | SRCPRKACAPRKACGPRKACBGPR35 | |
| SCHEMBL3883791 | 0.80 | SRC (1.00) | SRCPRKACAPRKACGPRKACBGPR35 | |
| SCHEMBL7980275 | 0.79 | SRC (0.66) | SRCDAODDOPARP1 | |
| SCHEMBL7784305 | 0.78 | SRC (0.62) | SRCPRKACAPRKACGPRKACBDAO | |
| SCHEMBL7984263 | 0.75 | SRC (1.00) | SRCPRKACAPRKACGPRKACBDAO | |
| SCHEMBL2547457 | 0.74 | SRC (0.58) | SRCPRKACAPRKACGPRKACBPARP1 | |
| SCHEMBL26775605 | 0.72 | SRC (0.54) | SRCPRKACAPRKACGPRKACBDAO | |
| SCHEMBL26775390 | 0.72 | SRC (0.54) | SRCPRKACAPRKACGPRKACBDAO | |
| SCHEMBL26768902 | 0.72 | SRC (0.54) | SRCPRKACAPRKACGPRKACBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |