Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976282 | 0.90 | FLT1 (0.40) | KDM1AKDRFLT1FLT4FNTA | |
| SCHEMBL7506878 | 0.89 | KDR (0.41) | KDM1AKDRFLT1FLT4ALPL | |
| SCHEMBL7507268 | 0.89 | KDR (0.46) | KDM1AKDRFLT1FLT4FNTA | |
| SCHEMBL7987165 | 0.84 | KDR (0.51) | KDM1AKDRMAPKAPK2PTPN11ALPL | |
| SCHEMBL7511883 | 0.84 | KDR (0.58) | KDM1AKDRFLT1FLT4NR3C1 | |
| SCHEMBL7503782 | 0.83 | KDR (0.41) | KDRFLT1FLT4FNTAFNTB | |
| SCHEMBL7511432 | 0.83 | KDM1A (0.44) | KDM1AMAPKAPK2PTPN11ALPLGRIN1 | |
| SCHEMBL7987153 | 0.79 | KDR (0.50) | KDM1AKDRFLT1FLT4MAPKAPK2 | |
| SCHEMBL7505010 | 0.78 | KDR (0.58) | KDRFLT1FLT4PDE4BMAP4K4 | |
| SCHEMBL7554511 | 0.78 | KDR (0.51) | KDM1AKDRFLT1FLT4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2001040198-A2 | MACROCYCLIC HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS ANTIMICROBIAL AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-06-07 | — | — | WO | disclosed |