Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988550 | 0.94 | ALDH1A1 (0.44) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7984240 | 0.90 | LMNA (0.58) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7974010 | 0.89 | SMN1; SMN2 (0.53) | CNOT7PIN1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL7974290 | 0.88 | KDM4E (0.50) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7986351 | 0.88 | KDM4E (0.50) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7992300 | 0.88 | LMNA (0.50) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7984893 | 0.85 | KDM4E (0.50) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7973624 | 0.84 | SMN1; SMN2 (0.48) | MAPK1SMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL7987629 | 0.84 | CNOT7 (0.52) | KDM4ELMNAPOLBMAPK1CNOT7 | |
| SCHEMBL7988662 | 0.83 | SMN1; SMN2 (0.53) | MAPK1CNOT7SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |