Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.74 |
| ▸ | FLT1 | P17948 | 5/20 | 0.74 |
| ▸ | FLT4 | P35916 | 5/20 | 0.74 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990663 | 0.92 | KDR (0.73) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7550594 | 0.89 | KDR (0.56) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7545744 | 0.88 | KDR (0.75) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7991015 | 0.87 | KDR (0.59) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7986894 | 0.87 | KDR (0.74) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7549555 | 0.87 | KDR (0.56) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7977669 | 0.86 | KDR (0.78) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7990446 | 0.86 | KDR (0.56) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7990472 | 0.85 | KDR (0.53) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7506453 | 0.85 | KDR (1.00) | KDRFLT1FLT4CNR2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |