Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | FLT4 | P35916 | 3/20 | 0.59 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550594 | 0.94 | KDR (0.56) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7990446 | 0.93 | KDR (0.56) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7550504 | 0.91 | KDR (0.59) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7990472 | 0.91 | KDR (0.53) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7987902 | 0.90 | KDR (0.53) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7990662 | 0.89 | KDR (0.68) | KDRFLT1FLT4CNR2MKNK2 | |
| SCHEMBL7990934 | 0.88 | KDR (0.66) | KDRFLT1FLT4MKNK2GSK3B | |
| SCHEMBL7987864 | 0.87 | KDR (0.74) | KDRFLT1FLT4CNR2HTR6 | |
| SCHEMBL7990519 | 0.87 | KDR (0.53) | KDRFLT1FLT4CNR2MKNK2 | |
| SCHEMBL7976794 | 0.86 | KDR (0.53) | KDRFLT1FLT4CNR2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |