Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | FLT1 | P17948 | 4/20 | 0.63 |
| ▸ | FLT4 | P35916 | 4/20 | 0.63 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506521 | 0.94 | KDR (0.60) | KDRFLT1FLT4MAT2APRKACA | |
| SCHEMBL7513664 | 0.93 | KDR (0.59) | KDRFLT1FLT4MAT2APRKACA | |
| SCHEMBL7990966 | 0.92 | KDR (0.63) | KDRFLT1FLT4MAT2APRKACA | |
| SCHEMBL7976518 | 0.89 | KDR (0.72) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7550357 | 0.89 | KDR (0.78) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7553739 | 0.89 | KDR (0.54) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7552655 | 0.88 | KDR (0.54) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7994231 | 0.87 | KDR (0.70) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7976429 | 0.87 | KDR (0.78) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7977281 | 0.86 | KDR (0.61) | KDRFLT1FLT4PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |