Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182285 | 0.83 | CAPN1 (0.39) | CAPN1GAACYP26A1CA2MAPT | |
| SCHEMBL8890406 | 0.83 | CA3 (0.42) | CA2ESR1ESR2DAO | |
| SCHEMBL11262445 | 0.83 | MDM2 (0.44) | CA2DAO | |
| SCHEMBL7217161 | 0.83 | MAPT (0.49) | CYP26A1CA2MAPT | |
| SCHEMBL8312946 | 0.81 | CYP4F2 (0.39) | GAACA2DAO | |
| SCHEMBL7165615 | 0.81 | PPARG (0.41) | CA2ESR1ESR2DAO | |
| SCHEMBL8315754 | 0.81 | FFAR1 (0.48) | GAA | |
| SCHEMBL8887933 | 0.80 | CYP4F2 (0.41) | GAAESR1ESR2DAO | |
| SCHEMBL8181670 | 0.79 | MAPT (0.40) | CA2MAPTDRD2XIAPBIRC2 | |
| SCHEMBL7164843 | 0.79 | ESR1 (0.42) | GAAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559690-A1 | 8-ENE-19, 11-g(b)-BRIDGED STEROIDS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM. | SCHERING AG (DE) | 1993-09-15 | — | — | EP | claimed |
| CN-101463031-B | Indazole and tetrahydrochysene indazole compounds, and preparation, pharmaceutical composition and use thereof | INST MATERIA MEDICA CAMS | 2014-02-12 | — | — | CN | disclosed |
| CN-101463031-A | Indazole and tetrahydrochysene indazole compounds, and preparation, pharmaceutical composition and use thereof | INST MATERIA MEDICA CAMS (CN) | 2009-06-24 | — | — | CN | disclosed |
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |
| EP-0991632-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057941-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |
| US-5391565-A | Hypoglycemic agents; antilipemic agents; hypotensive agents | BEECHAN GROUP P.L.C. (GB) | 1995-02-21 | — | — | US | disclosed |
| EP-0542816-A1 | OXAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-05-26 | — | — | EP | disclosed |
| WO-1992002520-A1 | OXAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP P.L.C. (GB) | 1992-02-20 | — | — | WO | disclosed |