Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20509684 | 0.89 | SIRT6 (0.81) | SIRT6MAPTALDH1A1MAPK1LMNA | |
| SCHEMBL44878 | 0.88 | SIRT6 (0.79) | SIRT6MAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL3049167 | 0.86 | MAPT (0.62) | SIRT6MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL23044900 | 0.86 | SIRT6 (0.61) | SIRT6MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3463899 | 0.83 | MAPT (0.59) | SIRT6MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL22652232 | 0.82 | SIRT6 (1.00) | SIRT6MAPTALDH1A1MAPK1HTR6 | |
| SCHEMBL21683030 | 0.81 | SIRT6 (0.76) | SIRT6MAPTALDH1A1MAPK1LMNA | |
| SCHEMBL2202741 | 0.81 | ALDH1A1 (0.78) | SIRT6MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5624466 | 0.81 | SIRT6 (0.76) | SIRT6MAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1414539 | 0.80 | MAPT (0.64) | SIRT6MAPTALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333320-B1 | USEFUL AS DRUGS, ESPECIALLY AS AN ACTIVATED BLOOD COAGULATION FACTOR X INHIBITOR | Yamanouchi Pharmaceutical Co. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1000936-A1 | NOVEL HEXAHYDRO-1,4-DIAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-05-17 | — | — | EP | disclosed |