Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | BAD | Q92934 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549814 | 0.95 | FLT1 (0.47) | KDRKMT2AKDM4EALDH1A1AVPR1B | |
| SCHEMBL7990656 | 0.93 | CYP1A2 (0.48) | KDRALDH1A1AVPR1BNPSR1FLT1 | |
| SCHEMBL7994209 | 0.92 | KDR (0.46) | KDRKMT2AKDM4EALDH1A1ROCK2 | |
| SCHEMBL7554912 | 0.91 | KDR (0.50) | KDRKMT2AHRH3FLT1FLT4 | |
| SCHEMBL7993627 | 0.90 | KDR (0.45) | KDRKMT2AAVPR1BHRH3FLT1 | |
| SCHEMBL7550186 | 0.89 | KDR (0.49) | KDRKMT2AKDM4EALDH1A1KCNH2 | |
| SCHEMBL7551275 | 0.88 | KDR (0.47) | KDRKMT2AKDM4EALDH1A1KCNH2 | |
| SCHEMBL7987156 | 0.87 | KDR (0.46) | KDRKMT2AKDM4EFLT1FLT4 | |
| SCHEMBL7549576 | 0.86 | KDR (0.51) | KDRKMT2AKDM4EALDH1A1HRH3 | |
| SCHEMBL7551621 | 0.86 | KDR (0.64) | KDRKMT2AFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |