Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | IL1B | P01584 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555418 | 0.95 | KDR (0.47) | KDRFLT1FLT4SMYD2MEN1 | |
| SCHEMBL7993627 | 0.92 | KDR (0.45) | KDRFLT1FLT4SMYD2SMN1; SMN2 | |
| SCHEMBL7991040 | 0.92 | FLT1 (0.47) | KDRFLT1FLT4SMN1; SMN2CNR1 | |
| SCHEMBL7554912 | 0.92 | KDR (0.50) | KDRFLT1FLT4SMYD2SMN1; SMN2 | |
| SCHEMBL7994209 | 0.92 | KDR (0.46) | KDRFLT1FLT4SMYD2SMN1; SMN2 | |
| SCHEMBL7551283 | 0.88 | KDR (0.49) | KDRFLT1FLT4SMYD2SLC6A4 | |
| SCHEMBL7987672 | 0.88 | KDR (0.47) | KDRFLT1FLT4SMYD2 | |
| SCHEMBL7987965 | 0.87 | KDR (0.45) | KDRFLT1FLT4KMT2AKDM4E | |
| SCHEMBL7549576 | 0.87 | KDR (0.51) | KDRFLT1FLT4SMYD2MEN1 | |
| SCHEMBL7551275 | 0.87 | KDR (0.47) | KDRFLT1FLT4SMYD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |