Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987965 | 0.93 | KDR (0.45) | FLT1FLT4KDRALDH1A1AVPR1B | |
| SCHEMBL7976639 | 0.93 | FLT1 (0.47) | HSD17B10FLT1FLT4KDRCNR1 | |
| SCHEMBL7508991 | 0.92 | CNR1 (0.51) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7986724 | 0.90 | FLT1 (0.46) | TP53FLT1FLT4KDRCNR1 | |
| SCHEMBL7550186 | 0.88 | KDR (0.49) | FLT1FLT4KDRALDH1A1GSK3B | |
| SCHEMBL7549814 | 0.88 | FLT1 (0.47) | FLT1FLT4KDRALDH1A1AVPR1B | |
| SCHEMBL7991040 | 0.88 | FLT1 (0.47) | TP53FLT1FLT4KDRCNR1 | |
| SCHEMBL7513681 | 0.86 | KDR (0.65) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7553606 | 0.85 | KDR (0.49) | CYP1A2CYP3A4CYP2D6LMNATP53 | |
| SCHEMBL7994209 | 0.85 | KDR (0.46) | CYP1A2CYP2D6ALOX15FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |